After an episode of depression, almost half of the patients have impaired cognition (executive functioning, memory, attention), which results in poorer functioning and higher risk of relapse. in a study published in Biological Psychiatry CNNI, Muzaffer Kaser and colleagues suggest that modafinil improves memory in those patients. Modafinil is a a wake-promoting agent approved by the FDA for the treatment of narcolepsy and shift work sleep disorder. In a double-blind, randomized study, they compared two groups patients in remitted depression (30 who took a single-dose of 200 mg modafinil vs. 30 who took a single dose of placebo) for cognition and fatigue .
They found that modafinil improves episodic and working memory but has no effect on attention, planning, or fatigue. They hypothesize that patients recovering from depression have a dysfunction in the hippocampal areas of the brain. Modafinil could improve memory by releasing the neurotransmitter glutamate in the hippoccampus.